Granulomatosis with polyangiitis in Northeastern Brazil: study of 25 cases and review of the literature

Table 2 Frequency of clinical manifestations in 25 patients from Northeastern Brazil diagnosed with granulomatosis with polyangiitis (GPA) between 2005 and 2016

Organ/system (n = 25)	n (%)	Clinical manifestation	n (%)
Kidney	16 (64)	Nephritic syndrome	13/16 (81)
		Creatinine clearance < 50 mL/min at diagnosis	12/16 (75)
		Microscopic hematuria at presentation	12/16 (75)
		Proteinuria > 1 g/day (mg/24 h)	8/16 (50)
		Proteinuria > 1 g/day (mg/24 h) at presentation	6/16 (38)
		Nephrotic-range proteinuria	5/16 (31)
		Chronic kidney disease requiring dialysis	4/16 (25)
Nose, ear, throat	16 (64)	Sinusitis	15/16 (93)
		Sensorineural deafness	3/16 (18)
		Mastoiditis	2/16 (13)
Lung	15 (60)	Pulmonary nodule	7/15 (47)
		Alveolar hemorrhage	4/15 (27)
		Bronchial stenosis	2/15 (13)
Constitutional manifestations	12 (48)	Fever	9/12 (75)
Constitutional manifestations	12 (48)	Asthenia	2/12 (17)
Joints	11 (44)	Oligo/polyarthritis	11/11 (100)
Skin	8 (32)	Purpura of lower limbs	8/8 (100)
Skin	8 (32)	Churg-Strauss nodule	1/8 (13)
Peripheral nervous system	7 (28)	Axonal polyneuropathy	4/7 (57)
		Multiple mononeuritis	2/7 (28)
		Facial nerve paralysis	1/7 (14)
Eyes	7 (28)	Orbital pseudotumor	3/7 (42)
		Scleritis	3/7 (42)
		Conjunctivitis	2/7 (28)
		Uveitis	1/7 (14)
Heart	4 (16)	Mitral insufficiency	2/4 (50)
		Congestive heart failure	1/4 (25)
		Third-degree atrioventricular block	1/4 (25)
Central nervous system	1 (4)	Transverse myelitis	1/1 (100)
Gastrointestinal tract	1 (4)	Bloody diarrhea	1/1 (100)

ISSN: 2523-3106