Table 6 Relationship between double positivity of anti-nuclesome and anti-C1q antibodies and other disease parameters among patients under study
|
Variable n (%) or mean±SD |
Double Positive (n=22) |
Double Negative (n=19) | t/x² | P value | |
|---|---|---|---|---|---|
| Clinical features | Arthritis | 19 (86.4) | 18 (94.7) | 0.812 | 0.368 |
| Pleurisy | 14 (63.6) | 13 (68.4) | 0.104 | 0.747 | |
| Fever | 14 (63.6) | 7 (36.8) | 2.930 | 0.087 | |
| Malar rash | 11 (50.0) | 14 (73.7) | 2.403 | 0.121 | |
| Oral ulcers | 12 (54.5) | 9 (47.4) | 0.21 | 0.647 | |
| Alopecia | 10 (45.5) | 9 (47.4) | 0.015 | 0.902 | |
| Photosensitivity | 6 (27.3) | 11 (57.9) | 3.939 | 0.047 | |
| Neurologic manifestations | 5 (22.7) | 6 (31.6) | 0.407 | 0.524 | |
| APS | 5 (22.7) | 6 (31.6) | 0.407 | 0.524 | |
| Vasculitis | 8 (36.4) | 1 (5.3) | 5.756 | 0.016 | |
| Pericarditis | 5 (22.7) | 2 (10.5) | 1.072 | 0.301 | |
| Discoid rash | 3 (13.6) | 1 (5.3) | 0.812 | 0.368 | |
| Myositis | 0 (0.0) | 0 (0.0) | -- | -- | |
| Nephritis | 15 (68.18) | 8 (42.1) | 3.051 | 0.217 | |
| ECLAM | 4.6±2.1 | 3.1±2.1 | 2.254 | 0.030 | |
| Laboratory features | ESR (mm/1st hour) | 59.6±32.3 | 37.0±25.1 | 2.471 | 0.018 |
| Serum creatinine (μmol/L ) | 0.7±0.3 | 0.9±0.4 | 1.443 | 0.157 | |
| Serum albumin (g/dl) | 3.6±0.5 | 4.2±0.8 | 2.960 | 0.005 | |
| Low C3 < 90 (mg/dl) | 14 (63.6) | 5 (26.3) | 5.711 | 0.017 | |
| Low C4 < 10 (mg/dl) | 7 (31.8) | 5 (15.8) | 1.420 | 0.233 | |
| 24 hours urinary proteins (gm/24hrs) | 2.1±2.0 | 1.6±1.5 | 0.606 | 0.551 | |